Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a therapeutic target for vascular calcification | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dichloroacetate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + SMAD1/5/8 protein | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16654 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + SMAD1/5/8 protein | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDK4 | - |
Homo sapiens |
pyruvate dehydrogenase kinase 4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition ameliorates the calcification in phosphate-treated vascular smooth muscle cells and aortic rings | Homo sapiens |
physiological function | the enzyme augments the osteogenic differentiation of vascular smooth muscle cells by phosphorylating SMAD1/5/8 via direct interaction, which enhances BMP2 signaling | Homo sapiens |