Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HMC-1 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GRK2 | - |
Homo sapiens |
GRK3 | - |
Homo sapiens |
GRK5 | - |
Homo sapiens |
GRK6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | GRK5 or GRK6 knockdown has no effect on C3aR (G protein coupled receptors for C3a) desensitization, but causes a significant decrease in C3a-induced mast cell degranulation. GRK5 or GRK6 knockdown render mast cells more responsive to C3a for ERK1/2 phosphorylation | Homo sapiens |
malfunction | knockdown of GRK2 or GRK3 expression using shRNA causes a more sustained Ca2+ mobilization, attenuated C3aR (G protein coupled receptors for C3a) desensitization, and enhanced degranulation as well as ERK1/2 phosphorylation when compared to shRNA control cells | Homo sapiens |
physiological function | GRK2 and GRK3 are involved in C3aR (G protein coupled receptors for C3a) desensitization | Homo sapiens |
physiological function | GRK5 and GRK6 promote C3a-induced mast cell degranulation but inhibit ERK1/2 phosphorylation via C3aR desensitization-independent mechanisms | Homo sapiens |