Activating Compound | Comment | Organism | Structure |
---|---|---|---|
diacylglycerol | - |
Rattus norvegicus | |
additional information | no activation by C2 ceramide or chronic insulin treatment | Rattus norvegicus | |
phorbol 12-myristate 13-acetate | stimulates IRS1 Ser24 phosphorylation in vivo | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Gรถ6976 | an inhibitor of isozymes cPKCalpha, -beta, and -my | Rattus norvegicus | |
Gรถ6983 | an inhibitor of isozyme PKCbeta, but not of PKCmy | Rattus norvegicus | |
rottlerin | a selective inhibitor of nPKCdelta and PKCtheta | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + insulin receptor substrate 1 | Rattus norvegicus | phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview | ADP + phosphorylated insulin receptor substrate 1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
several PKC isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | NIH/hIR/rIRS1cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + insulin receptor substrate 1 | phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview | Rattus norvegicus | ADP + phosphorylated insulin receptor substrate 1 | - |
? | |
ATP + insulin receptor substrate 1 | a bona fide substrate for conventional isozymes PKCalpha, PKCzeta, and PKCdelta, phosphorylation of IRS1 at Ser24 in the N-terminal pleckstrin homology domain of IRS1, additionally isozyme PKCalpha is indirectly involved in Ser307 and Ser612 phosphorylation | Rattus norvegicus | ADP + phosphorylated insulin receptor substrate 1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |