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Literature summary for 2.7.11.12 extracted from

  • Zhang, Y.; Yan, L.; Liu, J.; Cui, S.; Qiu, J.
    cGMP-dependent protein kinase II determines beta-catenin accumulation that is essential for uterine decidualization in mice (2019), Am. J. Physiol. Cell Physiol., 317, C1115-C1127 .
    View publication on PubMed
Search for more literature for 2.7.11.12

Inhibitors

Inhibitors Comment Organism Structure
5-(piperazine-1-sulfonyl)isoquinoline
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GSK-3beta protein Mus musculus the enzyme phosphorylates GSK-3beta at serine-9 and inactivates it leading to the accumulation of beta-catenin and promoting the process of decidualization ADP + GSK-3beta phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
 Mus musculus
-
chondrocyte
-
 Mus musculus
-
small intestine secretory epithelium of small intestine Mus musculus
-
uterine endometrial stromal cell
-
 Mus musculus
-
uterus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GSK-3beta protein the enzyme phosphorylates GSK-3beta at serine-9 and inactivates it leading to the accumulation of beta-catenin and promoting the process of decidualization Mus musculus ADP + GSK-3beta phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase II
-
 Mus musculus
Prkg2
-
 Mus musculus
Type II cGMP-dependent protein kinase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme has a gradually increased expression pattern during peri-implantation and artificial decidualization, and the enzyme expression is induced by estrogen and progesterone in the ovariectomized mouse uteri and primary cultured uterine stromal cells up

General Information

General Information Comment Organism
malfunction enzyme inhibition promotes uterine stromal cell proliferation Mus musculus
physiological function the enzyme has potential functions during decidualization Mus musculus