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Literature summary for 2.7.11.12 extracted from

  • Fiedler, B.; Feil, R.; Hofmann, F.; Willenbockel, C.; Drexler, H.; Smolenski, A.; Lohmann, S.M.; Wollert, K.C.
    cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes (2006), J. Biol. Chem., 281, 32831-32840.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Mus musculus
cGMP
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of FLAG-tagged p38alpha MAPK, and PKG Ialpha or PKG I-DELTAN1-92 plasmid expression vectors, and stimulation with 8-pCPT-cGMP, in HEK-293 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information constructing PKG I-DELTAN1-92, a PKG I mutant lacking the N-terminal 92 amino acids Rattus norvegicus
additional information during ischemia and reperfusion in vivo, mice with a cardiac myocyte-restricted deletion of PKG I display a more pronounced interaction of TAB1 with p38MAPK and a stronger phosphorylation of p38 MAPK in the myocardial area at risk during reperfusion and more apoptotic cardiac myocytes in the infarct border zone as compared to wild-type littermates Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview ?
-
 ?
additional information Rattus norvegicus cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview ?
-
 ?
additional information Mus musculus C57BL/6 cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6
-
Mus musculus C57BL/6
-
 C57BL/6
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-
cardiomyocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview Mus musculus ?
-
 ?
additional information cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview Rattus norvegicus ?
-
 ?
additional information cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase type I
-
 Mus musculus
cGMP-dependent protein kinase type I
-
 Rattus norvegicus
PKGI
-
 Mus musculus
PKGI
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus