Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pazopanib | i.e. 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulphonamide, potent inhibitor of vascular endothelial growth factor receotors 1, 2, and 3, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor beta, and KIT | Homo sapiens | |
sorafenib | - |
Homo sapiens | |
sunitinib | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KIT | - |
Homo sapiens |
PDGFR-alpha | isoform | Homo sapiens |
PDGFR-beta | isoform | Homo sapiens |
platelet-derived growth factor receptor | - |
Homo sapiens |
vascular endothelial growth factor | - |
Homo sapiens |
VEGFR1 | isoform | Homo sapiens |
VEGFR2 | isoform | Homo sapiens |
VEGFR3 | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |