Cloned (Comment) | Organism |
---|---|
transient expression of HA-tagged isozymes SphK1 and SphK2 in CHO-K1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-amino-4-(4-octylphenyl)butan-1-ol | i.e. (R)-2-amino-4-(4-octylphenyl)butan-1-ol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
(2R,3S)-3-amino-4-morpholin-4-yl-1-phenylbutan-2-ol | i.e. (2R,3S)-3-amino-4-morpholino-1-phenylbutan-2-ol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
(2S,3R)-2-amino-4-(4-octylphenyl)butane-1,3-diol | i.e. (2S,3R)-2-amino-4-(4-octylphenyl)butane-1,3-diol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
(2S,3S)-2-amino-4-(4-octylphenyl)butane-1,3-diol | i.e. (2S,3S)-2-amino-4-(4-octylphenyl)butane-1,3-diol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
additional information | inhibitors of isozyme SphK2 are cytotoxic, overview, inhibitory potency of the synthetic sphingosine analogues on isozymes SphK1 and SphK2, overview | Homo sapiens | |
N,N-dimethylsphingosine | inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide | i.e. N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1R)-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide | i.e. N-((R)-1-hydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1R)-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]decanamide | i.e. N-((R)-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S)-1-methyl-3-phenylpropyl]hexadecanamide | i.e. N-((R)-1-hydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]hexadecanamide | i.e. N-((2S,3R)-1,3-dihydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide | i.e. N-((2S,3R)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2R)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]octadecanamide | i.e. N-((2S,3R)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)stearamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2S)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]hexadecanamide | i.e. N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2S)-2-hydroxy-1-(morpholin-4-ylmethyl)-3-phenylpropyl]decanamide | i.e. N-((2S,3S)-3-hydroxy-1-morpholino-4-phenylbutan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2S)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]decanamide | i.e. N-((2S,3S)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens | |
N-[(1S,2S)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]octadecanamide | i.e. N-((2S,3S)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)stearamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | Homo sapiens | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes SphK1 and SphK2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phytosphingosine | low activity | Homo sapiens | ADP + phytosphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis | ? | |
additional information | FYT720 is no substrate of isozymes SphK1 and SphK2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sphinganine kinase | - |
Homo sapiens |
SPHK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |