BRENDA - Enzyme Database show
show all sequences of 2.7.1.82

Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline

Kersting, M.C.; Choi, H.S.; Carman, G.M.; J. Biol. Chem. 279, 35353-35359 (2004)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of the enzyme fused to the lacZ reporter gene in several yeast strains and in Escherichia coli strain DH5alpha, expression analysis in presence of inositol and choline in correlation to wild-type and mutated promotor
Saccharomyces cerevisiae
Inhibitors
Inhibitors
Commentary
Organism
Structure
Inositol
decreases gene EKI1 expression, involving the transcription factors Ino2p, Ino4p, and Opi1p, the UASINO element of the EKI promotor is required for the repressive regulation, the inhibitory effect on the enzyme is correlated with a decrease of ethanolamine incorporation into CDP-ethanolamine pathway intermediates and into phosphatidylethanolamine and phosphatidylcholine
Saccharomyces cerevisiae
additional information
enzyme expression is not affected by addition of choline
Saccharomyces cerevisiae
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + ethanolamine
Saccharomyces cerevisiae
the enzyme and the phospholipid phosphatidylethanolamine biosynthesis are regulated by inositol, Kennedy pathway overview
ADP + O-phosphoethanolamine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
gene EKI1
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + ethanolamine
-
662250
Saccharomyces cerevisiae
ADP + O-phosphoethanolamine
-
-
-
?
ATP + ethanolamine
the enzyme and the phospholipid phosphatidylethanolamine biosynthesis are regulated by inositol, Kennedy pathway overview
662250
Saccharomyces cerevisiae
ADP + O-phosphoethanolamine
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Saccharomyces cerevisiae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
assay at
Saccharomyces cerevisiae
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Saccharomyces cerevisiae
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of the enzyme fused to the lacZ reporter gene in several yeast strains and in Escherichia coli strain DH5alpha, expression analysis in presence of inositol and choline in correlation to wild-type and mutated promotor
Saccharomyces cerevisiae
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Inositol
decreases gene EKI1 expression, involving the transcription factors Ino2p, Ino4p, and Opi1p, the UASINO element of the EKI promotor is required for the repressive regulation, the inhibitory effect on the enzyme is correlated with a decrease of ethanolamine incorporation into CDP-ethanolamine pathway intermediates and into phosphatidylethanolamine and phosphatidylcholine
Saccharomyces cerevisiae
additional information
enzyme expression is not affected by addition of choline
Saccharomyces cerevisiae
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + ethanolamine
Saccharomyces cerevisiae
the enzyme and the phospholipid phosphatidylethanolamine biosynthesis are regulated by inositol, Kennedy pathway overview
ADP + O-phosphoethanolamine
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + ethanolamine
-
662250
Saccharomyces cerevisiae
ADP + O-phosphoethanolamine
-
-
-
?
ATP + ethanolamine
the enzyme and the phospholipid phosphatidylethanolamine biosynthesis are regulated by inositol, Kennedy pathway overview
662250
Saccharomyces cerevisiae
ADP + O-phosphoethanolamine
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Saccharomyces cerevisiae
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
assay at
Saccharomyces cerevisiae
Other publictions for EC 2.7.1.82
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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3
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Homo sapiens
Mol. Med. Rep.
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739295
Lin
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Arabidopsis thaliana
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1497-1511
2015
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Alberge
Comparison of the cellular and ...
Plasmodium falciparum, Plasmodium falciparum 3D7
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149-158
2010
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Gibellini
Biochemical characterization o ...
Trypanosoma brucei
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135-144
2008
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2
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692089
Gustin
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Mus musculus
Endocrinology
149
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2008
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693090
Signorell
Phosphatidylethanolamine is th ...
Trypanosoma brucei
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283
20320-20329
2008
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694838
Ding
The differential expression of ...
Anser sp.
Poult. Sci.
86
1206-1212
2007
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674547
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Regulation of the Saccharomyce ...
Saccharomyces cerevisiae
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281
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674650
Tian
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Mus musculus
J. Biol. Chem.
281
28438-28449
2006
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661557
Pascual
Ethanolamine kinase controls n ...
Drosophila melanogaster
Dev. Biol.
280
177-186
2005
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662250
Kersting
Regulation of the yeast EKI1-e ...
Saccharomyces cerevisiae
J. Biol. Chem.
279
35353-35359
2004
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641378
Aoyama
Expression and characterizatio ...
Mus musculus
Biochem. J.
363
777-784
2002
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642052
Lykidis
Overexpression of a mammalian ...
Homo sapiens
J. Biol. Chem.
276
2174-2179
2001
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642054
Nyako
Tissue-specific and developmen ...
Drosophila melanogaster
Biochem. Genet.
39
339-349
2001
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641383
Aoyama
Structure and characterization ...
Mus musculus
J. Lipid Res.
41
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2000
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642053
Kim
Isolation and characterization ...
Saccharomyces cerevisiae
J. Biol. Chem.
274
14857-14866
1999
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641381
Liu
Galactosemic cataractogenesis ...
Rattus norvegicus
Exp. Eye Res.
67
193-202
1998
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641379
Ishidate
Choline/ethanolamine kinase fr ...
Homo sapiens, Rattus norvegicus, Saccharomyces cerevisiae
Biochim. Biophys. Acta
1348
70-78
1997
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642056
Uchida
A novel high-molecular mass ma ...
Rattus norvegicus
Biochim. Biophys. Acta
1349
13-24
1997
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6
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642040
Draus
Isolation and characterization ...
Homo sapiens
Biochim. Biophys. Acta
1045
195-204
1990
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1
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2
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1
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1
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641345
Ishidate
Complete co-purification of ch ...
Rattus norvegicus
Biochim. Biophys. Acta
836
119-124
1985
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3
3
2
1
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3
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1
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1
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3
1
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1
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1
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641350
Ramabrahmam
Ethanolamine kinase from Culex ...
Culex quinquefasciatus
Arch. Biochem. Biophys.
207
55-62
1981
3
-
-
-
-
1
16
1
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2
1
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2
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1
1
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3
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1
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1
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3
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1
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16
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1
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2
1
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1
1
1
3
-
1
-
1
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-
-
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642039
Wharfe
Lipid metabolism in germinatin ...
Glycine max
Biochim. Biophys. Acta
575
102-111
1979
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-
-
-
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4
1
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1
2
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2
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1
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1
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2
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4
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1
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1
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2
1
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1
2
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1
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641347
Brophy
Choline kinase and ethanolamin ...
Rattus norvegicus
Eur. J. Biochem.
78
491-495
1977
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-
-
-
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9
2
3
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2
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1
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2
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1
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9
-
2
3
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2
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1
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641349
Spanner
Choline kinase and ethanolamin ...
Rattus norvegicus
Biochem. Soc. Trans.
5
164-165
1977
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-
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1
1
2
1
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2
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1
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3
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1
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1
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1
2
1
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3
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1
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1
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641346
Upreti
Likely individuality of the en ...
Capra hircus, Cavia porcellus, Columba livia, Duttaphrynus melanostictus, Gallus gallus, Hemidactylus sp., Heteropneustes fossilis, Hoplobatrachus tigerinus, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
174
658-665
1976
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10
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10
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10
-
3
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10
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10
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3
-
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10
-
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641354
Infante
Phospholipid synthesis in mamm ...
Bos taurus
Lipids
11
727-735
1976
-
-
-
-
-
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2
1
1
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2
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1
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1
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1
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1
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2
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1
1
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1
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1
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1
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642041
Macher
Partial purification and prope ...
Spinacia oleracea
Arch. Biochem. Biophys.
177
24-30
1976
1
-
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7
1
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1
1
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2
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1
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2
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1
1
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1
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1
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7
-
1
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1
1
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1
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2
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1
1
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1
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-
-
-
-
137599
Faulkner
-
Phosphorylation of ethanolamin ...
Achromobacter sp., Flavobacterium rhenanum, Microbacterium arborescens
Biochem. Soc. Trans.
2
133-136
1974
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5
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3
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6
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3
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12
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1
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1
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1
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5
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3
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6
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12
-
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1
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641348
Weinhold
The separation, purification, ...
Rattus norvegicus
Biochemistry
13
5135-5141
1974
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1
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2
2
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2
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1
1
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1
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2
2
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2
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642038
Weinhold
Ethanolamine phosphokinase: ac ...
Rattus norvegicus
Biochim. Biophys. Acta
276
143-154
1972
-
-
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9
1
1
1
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1
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1
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1
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1
1
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9
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1
1
1
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1
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1
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1
1
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641355
Shelley
-
Substrate specificity and inhi ...
Phormia regina
Insect Biochem.
1
149-156
1971
-
-
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2
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1
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1
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1
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1
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1
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1
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642036
Sung
Phosphorylation of choline and ...
Mus musculus
Biochem. J.
105
497-503
1967
-
-
-
-
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17
-
1
3
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1
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1
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1
1
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1
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1
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17
-
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1
3
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1
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1
1
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1
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1
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