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Literature summary for 2.7.1.74 extracted from

  • Fyrberg, A.; Albertioni, F.; Lotfi, K.
    Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes (2007), Biochem. Biophys. Res. Commun., 357, 847-853.
    View publication on PubMed
Search for more literature for 2.7.1.74

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell enzyme activity increases up to 3fold when cells start to proliferate Homo sapiens
-
HL60 cell enzyme activity increases up to 3fold when cells start to proliferate Homo sapiens
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K-562 cell
-
 Homo sapiens
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MOLT-4 cell enzyme activity increases up to 3fold when cells start to proliferate Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
additional information enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens