Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-cyclohexamidomanzamine A | noncompetitive inhibition | Mycobacterium tuberculosis | |
6-deoxymanzamine X | noncompetitive inhibition | Mycobacterium tuberculosis | |
8-hydroxymanzamine A | noncompetitive inhibition | Mycobacterium tuberculosis | |
manzamine A | noncompetitive inhibition | Mycobacterium tuberculosis | |
manzamine E | noncompetitive inhibition | Mycobacterium tuberculosis | |
manzamine F | noncompetitive inhibition | Mycobacterium tuberculosis | |
Rifampin | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 5 mM used in assay conditions | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | Mycobacterium tuberculosis | - |
ADP + 3-phosphoshikimate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | - |
Mycobacterium tuberculosis | ADP + 3-phosphoshikimate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0024 | - |
6-cyclohexamidomanzamine A | estimated Ki-value determined with varied shikimate concentrations and a fixed ATP concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.0032 | - |
6-cyclohexamidomanzamine A | estimated Ki-value determined with varied ATP concentrations and a fixed shikimate concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.011 | - |
8-hydroxymanzamine A | estimated Ki-value determined with varied ATP concentrations and a fixed shikimate concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.012 | - |
6-deoxymanzamine X | estimated Ki-value determined with varied shikimate concentrations and a fixed ATP concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.015 | - |
8-hydroxymanzamine A | estimated Ki-value determined with varied shikimate concentrations and a fixed ATP concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.021 | - |
6-deoxymanzamine X | estimated Ki-value determined with varied ATP concentrations and a fixed shikimate concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.022 | - |
manzamine F | estimated Ki-value determined with varied shikimate concentrations and a fixed ATP concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.04 | - |
manzamine F | estimated Ki-value determined with varied ATP concentrations and a fixed shikimate concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.058 | - |
manzamine E | estimated Ki-value determined with varied shikimate concentrations and a fixed ATP concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.063 | - |
manzamine E | estimated Ki-value determined with varied ATP concentrations and a fixed shikimate concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.12 | - |
manzamine A | estimated Ki-value determined with varied ATP concentrations and a fixed shikimate concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.151 | - |
manzamine A | estimated Ki-value determined with varied shikimate concentrations and a fixed ATP concentration, at pH 7.6 and 25°C | Mycobacterium tuberculosis |