BRENDA - Enzyme Database show
show all sequences of 2.7.1.60

Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium

Banerjee, S.; Ghosh, S.; Eur. J. Biochem. 8, 200-206 (1969)

Data extracted from this reference:

General Stability
General Stability
Organism
fairly stable, also stable to dialysis
Salmonella enterica subsp. enterica serovar Typhimurium
Inhibitors
Inhibitors
Commentary
Organism
Structure
p-chloromercuribenzoate
2-mercaptoethanol protects from inactivation
Salmonella enterica subsp. enterica serovar Typhimurium
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.75
-
N-acetyl-D-mannosamine
pH 7.6, 37°C
Salmonella enterica subsp. enterica serovar Typhimurium
1.15
-
ATP
pH 7.6, 37°C
Salmonella enterica subsp. enterica serovar Typhimurium
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Co2+
can replace Mg2+, but is less active
Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+
required for activity
Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+
can replace Mg2+, but is less active
Salmonella enterica subsp. enterica serovar Typhimurium
additional information
Ca2+, Na+ and K+ have no effect
Salmonella enterica subsp. enterica serovar Typhimurium
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + N-acetyl-D-mannosamine
Staphylococcus aureus
-
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Staphylococcus aureus
?
ATP + N-acetyl-D-mannosamine
Escherichia coli
-
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Escherichia coli
?
ATP + N-acetyl-D-mannosamine
Salmonella enterica subsp. enterica serovar Typhimurium
highly specific for ATP and N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + N-acetyl-D-mannosamine
Escherichia coli B / ATCC 11303
-
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Escherichia coli B / ATCC 11303
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Staphylococcus aureus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
58
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
Storage Stability
Storage Stability
Organism
4°C, loses about 33% of its activity during 7 days of storage
Salmonella enterica subsp. enterica serovar Typhimurium
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + N-acetyl-D-mannosamine
-
641731
Staphylococcus aureus
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Staphylococcus aureus
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Escherichia coli
?
ATP + N-acetyl-D-mannosamine
highly specific for ATP and N-acetyl-D-mannosamine
641731
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli B / ATCC 11303
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Escherichia coli B / ATCC 11303
?
ATP + N-acetyl-D-mannosamine
-
641731
Staphylococcus aureus
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Staphylococcus aureus
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Escherichia coli
?
ATP + N-acetyl-D-mannosamine
highly specific for ATP and N-acetyl-D-mannosamine
641731
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli B / ATCC 11303
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Escherichia coli B / ATCC 11303
?
additional information
glucose, mannose, fructose, glucosamine, N-acetylglucosamine and N-acetylgalactosamine are inactive as substrates
641731
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
-
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
70
-
stable to heating for a short period in a water-bath
Salmonella enterica subsp. enterica serovar Typhimurium
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.2
8.1
-
Salmonella enterica subsp. enterica serovar Typhimurium
6.5
8
-
Salmonella enterica subsp. enterica serovar Typhimurium
General Stability (protein specific)
General Stability
Organism
fairly stable, also stable to dialysis
Salmonella enterica subsp. enterica serovar Typhimurium
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
p-chloromercuribenzoate
2-mercaptoethanol protects from inactivation
Salmonella enterica subsp. enterica serovar Typhimurium
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.75
-
N-acetyl-D-mannosamine
pH 7.6, 37°C
Salmonella enterica subsp. enterica serovar Typhimurium
1.15
-
ATP
pH 7.6, 37°C
Salmonella enterica subsp. enterica serovar Typhimurium
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Co2+
can replace Mg2+, but is less active
Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+
required for activity
Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+
can replace Mg2+, but is less active
Salmonella enterica subsp. enterica serovar Typhimurium
additional information
Ca2+, Na+ and K+ have no effect
Salmonella enterica subsp. enterica serovar Typhimurium
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + N-acetyl-D-mannosamine
Staphylococcus aureus
-
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Staphylococcus aureus
?
ATP + N-acetyl-D-mannosamine
Escherichia coli
-
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Escherichia coli
?
ATP + N-acetyl-D-mannosamine
Salmonella enterica subsp. enterica serovar Typhimurium
highly specific for ATP and N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + N-acetyl-D-mannosamine
Escherichia coli B / ATCC 11303
-
ADP + N-acetyl-D-mannosamine 6-phosphate
-
Escherichia coli B / ATCC 11303
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
58
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
Storage Stability (protein specific)
Storage Stability
Organism
4°C, loses about 33% of its activity during 7 days of storage
Salmonella enterica subsp. enterica serovar Typhimurium
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + N-acetyl-D-mannosamine
-
641731
Staphylococcus aureus
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Staphylococcus aureus
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Escherichia coli
?
ATP + N-acetyl-D-mannosamine
highly specific for ATP and N-acetyl-D-mannosamine
641731
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli B / ATCC 11303
ADP + N-acetyl-D-mannosamine 6-phosphate
-
641731
Escherichia coli B / ATCC 11303
?
ATP + N-acetyl-D-mannosamine
-
641731
Staphylococcus aureus
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Staphylococcus aureus
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Escherichia coli
?
ATP + N-acetyl-D-mannosamine
highly specific for ATP and N-acetyl-D-mannosamine
641731
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + N-acetyl-D-mannosamine
-
641731
Escherichia coli B / ATCC 11303
ADP + N-acetyl-D-mannosamine-6-phosphate
-
641731
Escherichia coli B / ATCC 11303
?
additional information
glucose, mannose, fructose, glucosamine, N-acetylglucosamine and N-acetylgalactosamine are inactive as substrates
641731
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
-
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
70
-
stable to heating for a short period in a water-bath
Salmonella enterica subsp. enterica serovar Typhimurium
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.2
8.1
-
Salmonella enterica subsp. enterica serovar Typhimurium
6.5
8
-
Salmonella enterica subsp. enterica serovar Typhimurium
Other publictions for EC 2.7.1.60
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739115
Harazi
The interaction of UDP-N-acety ...
Homo sapiens
Mol. Neurobiol.
54
2928-2938
2017
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739177
Liu
Muscle biopsy and UDP-N-acetyl ...
Homo sapiens
NeuroReport
26
598-601
2015
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2
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739729
Hinderlich
-
UDP-GlcNAc 2-epimerase/ManNAc ...
Homo sapiens
Top. Curr. Chem.
366
97-138
2015
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2
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1
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1
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1
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728341
Grover
Role of UDP-N-acetylglucosamin ...
Homo sapiens
Mol. Neurobiol.
50
257-273
2014
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2
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3
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1
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737385
North
Cloning, expression, purificat ...
Staphylococcus aureus, Staphylococcus aureus USA300
Acta Crystallogr. Sect. F
70
643-649
2014
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722375
Yardeni
Murine isoforms of UDP-GlcNAc ...
Mus musculus
Glycoconj. J.
30
609-618
2013
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2
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1
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4
4
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722220
Kemmner
Loss of UDP-N-acetylglucosamin ...
Homo sapiens
FASEB J.
26
938-946
2012
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1
3
3
1
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722749
Martinez
Crystal structures of N-acetyl ...
Homo sapiens
J. Biol. Chem.
287
13656-13665
2012
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2
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2
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2
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723028
Mori-Yoshimura
Heterozygous UDP-GlcNAc 2-epim ...
Homo sapiens
J. Neurol. Sci.
318
100-105
2012
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4
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716189
Moeller
Efficient metabolic oligosacch ...
Homo sapiens
Mol. Biosyst.
7
2245-2251
2011
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1
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2
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721653
Yardeni
Identification, tissue distrib ...
Homo sapiens
Biochemistry
50
8914-8925
2011
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1
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1
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3
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706438
Tong
Crystal structure of the N-ace ...
Homo sapiens
PLoS ONE
4
e7165
2009
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694815
Amsili
UDP-N-acetylglucosamine 2-epim ...
Homo sapiens
PLoS ONE
3
e2477
2008
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1
1
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1
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705073
Ishihara
UDP-N-acetylglucosamine 2-epim ...
Homo sapiens
J. Med. Dent. Sci.
55
181-187
2008
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673693
Reinke
Prediction of three different ...
Homo sapiens
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Enhanced sialylation of EPO by ...
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672131
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Influence of UDP-GlcNAc 2-epim ...
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661666
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Localization of UDP-GlcNAc 2-e ...
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13
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661840
Sparks
Use of a cell-free system to d ...
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8
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661735
Hinderlich
The homozygous M712T mutation ...
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2004
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662186
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663299
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UDP-N-acetylglucosamine 2-epim ...
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1
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641701
Hinderlich
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1
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1
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641739
Effertz
Selective loss of either the e ...
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641740
Horstkorte
Tissue expression and amino ac ...
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3
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7
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9
2
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641741
Lucka
Primary structure and expressi ...
Homo sapiens
FEBS Lett.
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1999
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1
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1
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1
1
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1
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5
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1
2
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Hinderlich
Purification and characterizat ...
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6
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641738
Hinderlich
Metal ion requirement of bifun ...
Rattus norvegicus
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Hinderlich
A bifunctional enzyme catalyze ...
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1
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641735
Zeitler
Inhibition of N-acetylglucosam ...
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6
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6
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135465
Corfield
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1
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4
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641732
Banerjee
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N-Acetylmannosamnine kinase ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
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6
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1
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641731
Banerjee
Purification and properties of ...
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1
9
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1
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641730
Kundig
The sialic acids. VII. N-acyl- ...
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3
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1
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3
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1
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1
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1
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5
3
1
4
-
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641729
Ghosh
Enzymatic phosphorylation of N ...
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Biochemistry
47
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1961
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1
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1
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1
1
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3
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