Literature summary for 2.7.1.3 extracted from

Park, T.J.; Reznick, J.; Peterson, B.L.; Blass, G.; Omerbasic, D.; Bennett, N.C.; Kuich, P.H.J.L.; Zasada, C.; Browe, B.M.; Hamann, W.; Applegate, D.T.; Radke, M.H.; Kosten, T.; Lutermann, H.; Gavaghan, V.; Eigenbrod, O.; Begay, V.; Amoroso, V.G.; Govind, V.; Minshall, R.D.; Smith, E.S.J.; Larson, J.; Gotthard, M.
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat (2017), Science, 356, 307-311 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + D-fructose	Heterocephalus glaber	fructose enters glycolytic metabolism after phosphorylation by ketohexokinase and is converted to fructose-1-phosphate. Fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability	ADP + D-fructose 1-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Heterocephalus glaber	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Heterocephalus glaber	-
heart	-	Heterocephalus glaber	-
liver	-	Heterocephalus glaber	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-fructose	-	Heterocephalus glaber	ADP + D-fructose 1-phosphate	-	?
ATP + D-fructose	fructose enters glycolytic metabolism after phosphorylation by ketohexokinase and is converted to fructose-1-phosphate. Fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability	Heterocephalus glaber	ADP + D-fructose 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
KHK	-	Heterocephalus glaber
Khk-A	less efficient KHK-A isoform	Heterocephalus glaber
Khk-C	fructose selective KHK-C isoform	Heterocephalus glaber

General Information

General Information	Comment	Organism
metabolism	fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability	Heterocephalus glaber

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Release 2023.1 (January 2023)