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Literature summary for 2.7.1.3 extracted from

  • Le, M.; Lanaspa, M.; Cicerchi, C.; Rana, J.; Scholten, J.; Hunter, B.; Rivard, C.; Randolph, R.; Johnson, R.
    Bioactivity-guided identification of botanical inhibitors of ketohexokinase (2016), PLoS ONE, 11, e0157458.
    View publication on PubMed
Search for more literature for 2.7.1.3

Inhibitors

Inhibitors Comment Organism Structure
alpha-/gamma-mangostin
-
 Homo sapiens
cratoxyarborenone E
-
 Homo sapiens
methoxy-isobavachalcone
-
 Homo sapiens
additional information extracts of Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis exhibit ketohexokinase inhibitory activity and block fructose-induced ATP depletion and fructose-induced elevation in triglyerides and uric acid Homo sapiens
osthole
-
 Homo sapiens
phloretin Malus domestica extract, IC50 value 8.9–9.2 microg/mL Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 37°C, pH 7.2 Homo sapiens methoxy-isobavachalcone
0.0007
-
 37°C, pH 7.2 Homo sapiens osthole
0.001
-
 37°C, pH 7.2 Homo sapiens cratoxyarborenone E
0.0015
-
 37°C, pH 7.2 Homo sapiens alpha-/gamma-mangostin