Literature summary for 2.7.1.20 extracted from

Mori, K.; Hiraoka, O.; Ikeda, M.; Ariumi, Y.; Hiramoto, A.; Wataya, Y.; Kato, N.
Adenosine kinase is a key determinant for the anti-HCV activity of ribavirin (2013), Hepatology, 58, 1236-1244.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P55263	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Homo sapiens	-
Or-6 cell	HuH-7-derived cell, with ribavirin-resistant phenotype	Homo sapiens	-
Orl-8 cell	Li23-derived cell line, with ribavirin-sensitive phenotype	Homo sapiens	-
PH5CH-8 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	the expression of adenosine kinase in ribavirin-sensitive Orl-8 cells is significantly higher than that in ribavirin-resistant Or-6 cells harboring hepatitis C virus RNA. Ectopic adenosine kinase expression in Or-6 cells converts them from an ribavirin-resistant to an ribavirin-sensitive phenotype, and inhibition of adenosine kinase abolishes the activity of ribavirin. The differential adenosine kinase expression between is not the result of genetic polymorphisms in the adeosine kinase gene promoter region and is not mediated by a microRNA control mechanism. The 5' untranslated region of adenosine kinase messenger RNA in Orl-8 cells is longer than that in OR6 cells, and only a long 5' UTR possesses internal ribosome entry site activity	Homo sapiens

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Release 2023.1 (January 2023)