Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of PI3K-C2alpha by specific siRNA in human umbilical vein endothelial cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00443 | subunit alpha; gene PIK3C2A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class II PI3K-C2alpha | - |
Homo sapiens |
phosphatidylinositol 3-kinase class II alpha | - |
Homo sapiens |
PI3K-C2alpha | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | TGFbeta1 stimulated nuclear accumulation of p-Smad2 is markedly suppressed by PI3K-C2alpha knockdown. Effect of PI3K-C2alpha knockdown on the co-localization of TGFbeta1 receptors and SARA. PI3K-C2alpha knockdown does not affect the numbers of either SARA-positive or EEA1-positive vesicles in nonstimulated cells but abolished TGFbeta1-induced increase in SARA- and EEA1-double positive early endosomes | Homo sapiens |
physiological function | isozyme phosphatidylinositol 3-kinase class II alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells, but not in smooth muscle cells or epithelial cells. TGFbeta1-induced phosphorylation and nuclear translocation of Smad2/3 are dependent on class II PI3K-C2alpha. C2alpha is required for SARA-Smad2/3 complex formation | Homo sapiens |