Literature summary for 2.7.1.127 extracted from

Dean, D.; Maroja, L.; Cottrill, S.; Bomkamp, B.; Westervelt, K.; Deitcher, D.
The wavy mutation maps to the inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) gene of drosophila and interacts with IP3R to affect wing development (2016), G3 (Bethesda), 6, 299-310 .

Search for more literature for 2.7.1.127

Cloned(Commentary)

Cloned (Comment)	Organism
gene wavy, DNA and amino acid sequence determination and analysis, detailed analysis of genetic organization, overview	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
additional information	mutant alleles of wavy (wy), a classic locus of the fruit fly Drosophila melanogaster, map to IP3 3-kinase 2 (IP3K2), mapping of the wy locus. Mutations in wy disrupt wing structure in a highly specific pattern, wy alleles, mapping, complementation tests, RNAi experiments of IP3K2 (using VDRC v19159: P(GD8778)v19159/TM3 Sb), phenotype analysis, overview. All three mutant alleles of wy are dominantly suppressed by both mutant alleles of IP3R	Drosophila melanogaster

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate	Drosophila melanogaster	-	ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	A0A0U2TSJ5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate	-	Drosophila melanogaster	ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
IP3 3-kinase 2	-	Drosophila melanogaster
IP3K2	-	Drosophila melanogaster
wavy	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
evolution	enzyme IP3 3-kinase 2 (IP3K2) is a member of the inositol polyphosphate kinase gene family	Drosophila melanogaster
malfunction	mutant alleles of wavy (wy), a classic locus of the fruit fly Drosophila melanogaster, map to IP3 3-kinase 2 (IP3K2). Mutations in wy disrupt wing structure in a highly specific pattern. RNAi experiments using GAL4 and GAL80ts. Gradations in the severity of the wy phenotype provide high-resolution readouts of IP3K2 function and of overall IP3 signaling are analyzed. A dominant modifier screen reveals that mutations in IP3R strongly suppress the wy phenotype, suggesting that the wy phenotype results from reduced IP4 levels, and/or excessive IP3R signaling. Potential models for how IP3K2 affects wing morphology and how mutations in IP3R dominantly suppress the wy phenotype, modeling the interactions between wavy and IP3R, overview	Drosophila melanogaster
metabolism	inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP3. This limits IP3R activation by reducing IP3 levels, and also generates new signaling molecules altogether. The divergent pathways draw from the same IP3 pool yet cause very different cellular responses. Controlling the relative rates of IP3R activation vs. phosphorylation of IP3 is essential for proper cell functioning. Modeling the interactions between wavy and IP3R	Drosophila melanogaster
physiological function	IP3K2 function is required in the wing discs of early pupae for normal wing development. Controlling the relative rates of IP3R activation vs. phosphorylation of IP3 is essential for proper cell functioning. IP3K2 function is required in the developing wing blade during early pupal life	Drosophila melanogaster

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Release 2023.1 (January 2023)