Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyguanosine | Homo sapiens | - |
ADP + dGMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16854 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
lung adenocarcinoma cell | - |
Homo sapiens | - |
lung adenocarcinoma cell line | human lung adenocarcinoma cell line PDC-027 | Homo sapiens | - |
lung adenocarcinoma cell line | human lung adenocarcinoma cell line PDC-236 | Homo sapiens | - |
lung adenocarcinoma cell line | human lung adenocarcinoma cell line PDC-251 | Homo sapiens | - |
lung squamous cell carcinoma cell | - |
Homo sapiens | - |
NCI-H1650 cell | - |
Homo sapiens | - |
NCI-H292 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyguanosine | - |
Homo sapiens | ADP + dGMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGK | - |
Homo sapiens |
DGUOK | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the depletion of the enzyme robustly inhibits lung adenocarcinoma tumor growth, metastasis, and cancer stem-like cell self-renewal | Homo sapiens |
physiological function | the enzyme is required for cancer cell stemness in lung adenocarcinoma. The enzyme is required for the biogenesis of respiratory complex I and mitochondrial oxidative phosphorylation, which in turn regulates cancer stem-like cell self-renewal through AMP-activated kinase-YAP1 signaling | Homo sapiens |