Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose 6-phosphate | Homo sapiens | the enzyme catalyzes a rate-limiting reaction in glycolysis | ADP + D-fructose 1,6-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01813 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose 6-phosphate | - |
Homo sapiens | ADP + D-fructose 1,6-bisphosphate | - |
? | |
ATP + D-fructose 6-phosphate | the enzyme catalyzes a rate-limiting reaction in glycolysis | Homo sapiens | ADP + D-fructose 1,6-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PFKP | phosphofructokinase 1 platelet isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes a rate-limiting reaction in glycolysis. The enzyme (PFKP) promotes EGFR activation-induced nuclear translocation and activation of beta-catenin in a PFKP Y64 phosphorylation-dependent manner, thereby enhancing the expression of beta-catenin downstream genes CCND1 and MYC. Thus, PFKP Y64 phosphorylation enhances tumor cell migration, invasion, proliferation, and brain tumor growth | Homo sapiens |