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Literature summary for 2.7.1.107 extracted from

  • Fazio, A.; Obeng, E.; Rusciano, I.; Marvi, M.; Zoli, M.; Mongiorgi, S.; Ramazzotti, G.; Follo, M.; McCubrey, J.; Cocco, L.; Manzoli, L.; Ratti, S.
    Subcellular localization relevance and cancer-associated mechanisms of diacylglycerol kinases (2020), Int. J. Mol. Sci., 21, 1-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.107

Inhibitors

Inhibitors Comment Organism Structure
5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one
-
 Homo sapiens
R59022 i.e. 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one Homo sapiens
R59949 i.e. 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone Homo sapiens
ritanserin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
endoplasmic reticulum
-
 Homo sapiens 5783
-
endosome
-
 Homo sapiens 5768
-
Golgi apparatus
-
 Homo sapiens 5794
-
nucleus
-
 Homo sapiens 5634
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75912
-
-
Homo sapiens P23743
-
-
Homo sapiens P49619
-
-
Homo sapiens P52429
-
-
Homo sapiens P52824
-
-
Homo sapiens Q13574
-
-
Homo sapiens Q16760
-
-
Homo sapiens Q5KSL6
-
-
Homo sapiens Q86XP1
-
-
Homo sapiens Q9Y6T7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
cervical carcinoma cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
lung adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DGKalpha isoform Homo sapiens
DGKbeta isoform Homo sapiens
DGKdelta isoform Homo sapiens
DGKepsilon isoform Homo sapiens
DGKeta isoform Homo sapiens
DGKgamma isoform Homo sapiens
DGKiota isoform Homo sapiens
DGKkappa isoform Homo sapiens
DGKtheta isoform Homo sapiens
DGKzeta isoform Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme isoforms control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some enzyme isoforms control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA Homo sapiens