Application | Comment | Organism |
---|---|---|
medicine | glucokinase is a potential therapeutic target for treating maturity-onset diabetes of the young and persistent hyperinsulinemic hypoglycemia of infancy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli strain M15 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K169A | inactive, Lys169 enhances the binding of glucokinase with both ATP and glucose by serving as a bridge between ATP and glucose, Lys169 directly participates in the glucose phosphorylation as a general acid catalyst | Homo sapiens |
K169N | naturally occurring mutation in the glucokinase gene associated with familial mild fasting hyperglycemia | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
ATP | wild type enzyme, in 25 mM HEPES (pH 7.1), at 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19367 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA resin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glucokinase | - |
Homo sapiens |
LGK2 | - |
Homo sapiens |
liver glucokinase isoform 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |