Literature summary for 2.6.1.7 extracted from

Jayawickrama, G.S.; Nematollahi, A.; Sun, G.; Gorrell, M.D.; Church, W.B.
Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives (2017), Sci. Rep., 7, 17559 .

Search for more literature for 2.6.1.7

Inhibitors

Inhibitors	Comment	Organism	Structure
BFF-122	irreversible inhibitor; irreversible inhibitor	Homo sapiens
BFF-816	reversible inhibitor; reversible inhibitor	Homo sapiens
estradiol disulfate	strong reversible inhibitor; strong reversible inhibitor	Homo sapiens
Estrone sulfate	weak inhibitor	Homo sapiens
additional information	not inhibited by estradiol and estradiol 3-sulfate; not inhibited by estrone sulfate, estradiol and estradiol 3-sulfate	Homo sapiens
NS-1502	reversible inhibitor; reversible inhibitor	Homo sapiens
PF-04859989	irreversible inhibitor; irreversible inhibitor	Homo sapiens
S-4-(ethylsulfonyl)benzoyl-L-alanine	reversible inhibitor; reversible inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-kynurenine + 2-oxoglutarate	Homo sapiens	-	kynurenic acid + L-glutamate + H2O	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16773	-	-
Homo sapiens	Q8N5Z0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-kynurenine + 2-oxoglutarate	-	Homo sapiens	kynurenic acid + L-glutamate + H2O	-	ir

Subunits

Subunits	Comment	Organism
homodimer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
KAT-I	isoform	Homo sapiens
KAT-II	isoform	Homo sapiens
kynurenine aminotransferase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0263	-	isoform KAT-II, at pH 7.4 and 37°C	Homo sapiens	estradiol disulfate
0.2915	-	isoform KAT-I, at pH 7.4 and 37°C	Homo sapiens	estradiol disulfate

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Release 2023.1 (January 2023)