Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y142F | active site mutation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-2-amino-4-(4-(ethylsulfonyl)phenyl)-4-oxobutanoic acid | 71% inhibition at 1 mM, 63% inhibition at 0.1 mM, poor substrate that undergo slow transamination, KM-value 4.5 mM, Kcat-value 0.15 1/sec, pH 7.5, 25°C | Homo sapiens | |
cysteine sulfinate | poor substrate that undergoes slow transamination, KM-value 12.3 mM, pH 7.5, 25°C | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.96 | - |
L-kynurenine | discontinuous assay, pH 7.5, 45°C | Homo sapiens | |
1.2 | - |
2-oxoglutarate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
2.09 | - |
L-kynurenine | continuous assay, pH 7.5, 45°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + 2-oxoglutarate | - |
Homo sapiens | kynurenic acid + L-glutamate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kynurenine aminotransferase II | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.8 | - |
L-kynurenine | continuous assay, pH 7.5, 45°C | Homo sapiens | |
2.2 | - |
L-kynurenine | discontinuous assay, pH 7.5, 45°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
cysteine sulfinate | 17.2 mM dissociation constant for dissociation of the inhibitor from the enzyme substrate complex, pH 7.5, 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
pH 7.5, 25°C | Homo sapiens | cysteine sulfinate |