Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adipate | - |
Rattus norvegicus | |
azelaic acid | - |
Rattus norvegicus | |
Decanoic acid | - |
Rattus norvegicus | |
Diethylglutaric acid | - |
Rattus norvegicus | |
dimethylglutaric acid | - |
Rattus norvegicus | |
additional information | not inhibited by 2-aminoadipate; not inhibited by oxaloacetic acid, 3-methylglutaric acid | Rattus norvegicus | |
pimelate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
2-oxoglutarate | cosubstrate L-kynurenine | Rattus norvegicus | |
4 | - |
L-kynurenine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid composition | Rattus norvegicus |
44000 | - |
2 * 44000, SDS-PAGE | Rattus norvegicus |
91000 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.22 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3-hydroxykynurenine + 2-oxoglutarate | - |
Rattus norvegicus | xanthurenic acid + L-glutamate | - |
? | |
L-histidine + 2-oxoglutarate | - |
Rattus norvegicus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate | - |
? | |
L-kynurenine + 2-oxoglutarate | best substrates | Rattus norvegicus | kynurenic acid + L-glutamate + H2O | - |
? | |
L-kynurenine + pyruvate | less effective than 2-oxoglutarate | Rattus norvegicus | kynurenic acid + L-alanine + H2O | - |
? | |
L-tryptophan + 2-oxoglutarate | poor substrate | Rattus norvegicus | 3-indole-2-oxopropanoate + L-glutamate | - |
? | |
L-tyrosine + 2-oxoglutarate | - |
Rattus norvegicus | 3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 44000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
More | not identical with EC 2.6.1.39 | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pI: 5.9 | Rattus norvegicus |