Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the methanol extract from Melissa officinalis is a potent in vitro inhibitor of GABA-T with IC50 of 0.55 mg/ml, inhibition decreases in the order: methanol extract, water extract, ethyl acetate extract and hexane extract (not inhibitory) | Rattus norvegicus | |
oleanolic acid | 20.2% inhibition at 0.1 mg/ml | Rattus norvegicus | |
rosmarinic acid | 40.2% inhibition at 0.1 mg/ml | Rattus norvegicus | |
ursolic acid | 19.9% inhibition at 0.1 mg/ml | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanoate + 2-oxoglutarate | Rattus norvegicus | - |
4-oxobutanoate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanoate + 2-oxoglutarate | - |
Rattus norvegicus | 4-oxobutanoate + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GABA transaminase | - |
Rattus norvegicus |
GABA-T | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |