Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cys-Val-Phe-aminohexanoate | - |
Rattus norvegicus | |
Cys-Val-Phe-Cys | - |
Rattus norvegicus | |
Cys-Val-Phe-Met | - |
Rattus norvegicus | |
Cys-Val-Phe-Phe | - |
Rattus norvegicus | |
L-penicillamine-Ile-Ile-Met | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-Ala | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-aminohexanoate | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-Cys | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-Gln | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-homoserine | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-Met | - |
Rattus norvegicus | |
L-penicillamine-Val-Ile-Phe | - |
Rattus norvegicus | |
L-penicillamine-Val-Val-Met | - |
Rattus norvegicus | |
additional information | tetrapeptides with sequence L-penicillamine-Val-Ile-X and Cys-Val-Phe-X | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | comparison of KM-value of substrates with the structure Lys-Lys-Ser-Ser-Cys-Val-Ile-X for for farnesyltransferase and geranylgeranyltransferase | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | Rattus norvegicus | - |
S-farnesyl protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | substrate are: Ras superfamiliy and Ras-related proteins for example Rap, Rab, Rac and Ral, large G proteins, nuclear lamins, rhodopsin kinase and the retinal cGMP phosphodiesterase | Rattus norvegicus | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | enzyme prefers linear residues in the X position of the CaaX box over branched residues, enzyme prefers Gln, Met and Ser at the X position | Rattus norvegicus | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | - |
Rattus norvegicus | S-farnesyl protein + diphosphate | - |
? | |
farnesyl diphosphate + Ras-Cys-Val-Ile-Met | best substrate | Rattus norvegicus | diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | comparison of kcat-value of substrates with the structure Lys-Lys-Ser-Ser-Cys-Val-Ile-X for for farnesyltransferase and geranylgeranyltransferase | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | comparison of KI-values of tetrapeptide inhibitors L-penicillamine-Val-Ile-X and Cys-Val-Phe-X for farnesyltransferase and geranylgeranyltransferase | Rattus norvegicus | |
0.00008 | - |
Cys-Val-Phe-Met | - |
Rattus norvegicus | |
0.0003 | - |
L-penicillamine-Val-Ile-Gln | - |
Rattus norvegicus | |
0.00052 | - |
L-penicillamine-Ile-Ile-Met | - |
Rattus norvegicus | |
0.0008 | - |
L-penicillamine-Val-Ile-Cys | - |
Rattus norvegicus | |
0.00082 | - |
L-penicillamine-Val-Val-Met | - |
Rattus norvegicus | |
0.0011 | - |
L-penicillamine-Val-Ile-Met | - |
Rattus norvegicus | |
0.0017 | - |
L-penicillamine-Val-Ile-homoserine | - |
Rattus norvegicus | |
0.0028 | - |
Cys-Val-Phe-Phe | - |
Rattus norvegicus | |
0.0029 | - |
Cys-Val-Phe-Cys | - |
Rattus norvegicus | |
0.0034 | - |
L-penicillamine-Val-Ile-aminohexanoate | - |
Rattus norvegicus | |
0.0045 | - |
L-penicillamine-Val-Ile-Phe | - |
Rattus norvegicus | |
0.0053 | - |
L-penicillamine-Val-Ile-Ala | - |
Rattus norvegicus | |
0.0059 | - |
Cys-Val-Phe-aminohexanoate | - |
Rattus norvegicus |