Cloned (Comment) | Organism |
---|---|
expression in BL21 gold bacteria | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,6E)-farnesyl-bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
(2E,6E)-farnesyl-geranyl-bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
(2E,6Z)-farnesyl-bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
(3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | - |
Homo sapiens | |
(3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | - |
Homo sapiens | |
(3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | - |
Homo sapiens | |
(6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | - |
Homo sapiens | |
(6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | - |
Homo sapiens | |
(Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate | - |
Homo sapiens | |
bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
digeranyl bisphosphonate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
recombinant | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,trans-farnesyl diphosphate + isopentenyl diphosphate | - |
Homo sapiens | diphosphate + geranylgeranyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GGDPS | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
pH 7.5, 37°C | Homo sapiens | (2E,6E)-farnesyl-bis(phosphonic acid) | |
0.0002 | - |
- |
Homo sapiens | digeranyl bisphosphonate | |
0.0002 | - |
pH 7.5, 37°C | Homo sapiens | bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid) | |
0.0003 | - |
pH 7.5, 37°C | Homo sapiens | (2E,6E)-farnesyl-geranyl-bis(phosphonic acid) | |
0.0006 | - |
- |
Homo sapiens | (3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | |
0.0006 | - |
pH 7.5, 37°C | Homo sapiens | (2E,6Z)-farnesyl-bis(phosphonic acid) | |
0.003 | - |
- |
Homo sapiens | (6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | |
0.006 | - |
- |
Homo sapiens | (6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | |
0.007 | - |
- |
Homo sapiens | (Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate | |
0.04 | - |
- |
Homo sapiens | (3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | |
0.07 | - |
- |
Homo sapiens | (3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate |