Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
complex of isoform CD38 with substrate NMN shows that the nicotinamide moiety is in close contact with Glu146 at 3.27 A and Asp155 at 2.52 A. Residue Asp147 is situated and directed away from the bound substrate | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D147V | mutation has minimal effects on pH-dependence of the enzyme | Homo sapiens |
D155N | mutation eliminates the strong pH dependence of the catalyzed reactions | Homo sapiens |
D155Q | mutation eliminates the strong pH dependence of the catalyzed reactions | Homo sapiens |
D155Q | mutation preserves the strong pH dependence of the catalyzed reactions | Homo sapiens |
E146A | mutation eliminates the strong pH dependence of the catalyzed reactions | Homo sapiens |
E146G | mutation eliminates the strong pH dependence of the catalyzed reactions | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28907 | - |
- |