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Literature summary for 2.4.2.8 extracted from
- Plasma hypoxanthine-guanine phosphoribosyl transferase activity in bottlenose dolphins contributes to avoiding accumulation of non-recyclable purines (2016), Front. Physiol., 7, 213 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Homo sapiens | - |
- |
| soluble | - |
Tursiops truncatus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
GMP + diphosphate | - |
? |  |
| guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | Tursiops truncatus | - |
GMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
IMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Tursiops truncatus | - |
IMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00492 | - |
- |
| Tursiops truncatus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
| blood plasma | - |
Tursiops truncatus | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Tursiops truncatus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0007 | - |
enzyme activity in erythrocytes, pH 8.8, 25°C | Tursiops truncatus |
| 0.0021 | - |
enzyme activity in erythrocytes, pH 8.8, 25°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | GMP + diphosphate | - |
? | |
| guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Tursiops truncatus | GMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | IMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Tursiops truncatus | IMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HGPRT | - |
Homo sapiens |
| HGPRT | - |
Tursiops truncatus |
| hypoxanthine-guanine phosphoribosyl transferase | - |
Homo sapiens |
| hypoxanthine-guanine phosphoribosyl transferase | - |
Tursiops truncatus |
| plasma hypoxanthine-guanine phosphoribosyl transferase | - |
Homo sapiens |
| plasma hypoxanthine-guanine phosphoribosyl transferase | - |
Tursiops truncatus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
| 25 | - |
assay at | Tursiops truncatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.8 | - |
assay at | Homo sapiens |
| 8.8 | - |
assay at | Tursiops truncatus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is important in the purine metabolism pathways. Analysis and comparison of plasma and red blood cell hypoxanthine and inosine monophosphate concentrations and enzyme activities from bottlenose dolphins (Tursiops truncatus) and humans, overview. Hypoxanthine and inosine monophosphate concentrations are higher in plasma from dolphins than humans. Plasma hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity in dolphins suggests an elevated purine recycling rate, and a mechanism for avoiding accumulation of non-recyclable purines (xanthine and uric acid). Red blood cell concentrations of hypoxanthine, adenosine diphosphate, ATP, and guanosine triphosphate are lower in dolphins than in humans. Adenosine monophosphate and nicotinamide adenine dinucleotide concentrations are higher in dolphins. HGPRT activity in red blood cells is higher in humans than in dolphins. The lower concentrations of purine catabolism and recycling by-products in plasma from dolphins ca be beneficial in providing substrates for recovery of ATP-depletion during diving or vigorous swimming. The results suggest that purine salvage in dolphins could be a mechanism for delivering nucleotide precursors to tissues with high ATP and guanosine triphosphate requirements | Tursiops truncatus |
| metabolism | the enzyme is important in the purine metabolism pathways. Analysis and comparison of plasma and red blood cell hypoxanthine and inosine monophosphate concentrations and enzyme activities from bottlenose dolphins (Tursiops truncatus) and humans, overview. Hypoxanthine and inosine monophosphate concentrations are higher in plasma from dolphins than humans. Red blood cell concentrations of hypoxanthine, adenosine diphosphate, ATP, and guanosine triphosphate are lower in dolphins than in humans. Adenosine monophosphate and nicotinamide adenine dinucleotide concentrations are higher in dolphins. HGPRT activity in red blood cells is higher in humans than in dolphins | Homo sapiens |
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