Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Pb2+ | inhibits the enzyme in erythrocytes about 25% at 0.0005 mM and about 20% at 0.0001 mM, and participates in hemolysis, the intensity of which negatively correlates with the activity of phosphoribosyltransferases, APRT inhibition as one of the mechanisms of lead toxicity | Homo sapiens | |
Pb2+ | moderately inhibits both the enzyme in erythrocytes even at very low concentrations, and participates in hemolysis, the intensity of which negatively correlates with the activity of phosphoribosyltransferases, APRT inhibition as one of the mechanisms of lead toxicity | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
AMP + diphosphate | - |
? | |
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | Rattus norvegicus | - |
AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
erythrocyte | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activity in erythrocyte lysate in presence or absence of Pb2+, overview | Homo sapiens |
additional information | - |
enzyme activity in erythrocyte lysate in presence or absence of Pb2+, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | AMP + diphosphate | - |
? | |
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APRT | - |
Homo sapiens |
APRT | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme enables the reutilization of purine base adenine converting it to mononucleotide AMP, substrate for the synthesis of high-energy nucleotides | Homo sapiens |
physiological function | the enzyme enables the reutilization of purine base adenine converting it to mononucleotide AMP, substrate for the synthesis of high-energy nucleotides | Rattus norvegicus |