Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2-methyl-1H-indol-3-yl)-N'-(2,4,6-trihydroxybenzylidene)acetohydrazide | - |
Escherichia coli | |
2-(2-methyl-1H-indol-3-yl)-N'-(2-methylbenzylidene)acetohydrazide | - |
Escherichia coli | |
2-(2-methyl-1H-indol-3-yl)-N'-(2-nitrobenzylidene)acetohydrazide | - |
Escherichia coli | |
2-(2-methyl-1H-indol-3-yl)-N'-(3-methylbenzylidene)acetohydrazide | - |
Escherichia coli | |
2-(2-methyl-1H-indol-3-yl)-N'-(3-nitrobenzylidene)acetohydrazide | - |
Escherichia coli | |
2-(2-methyl-1H-indol-3-yl)-N'-(4-methylbenzylidene)acetohydrazide | - |
Escherichia coli | |
2-(2-methyl-1H-indol-3-yl)-N'-(4-nitrobenzylidene)acetohydrazide | - |
Escherichia coli | |
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride | TPI | Escherichia coli | |
7-deazaxanthine | 7DX | Escherichia coli | |
methyl-4-((2-(2-(2-methyl-1H-indol-3-yl)acetyl)hydrazono)methyl)benzoate | - |
Escherichia coli | |
additional information | synthesis of indole-based acetohydrazide derivatives as inhibitors and molecular docking study using structure with PDB ID 4EAD as template, re-docking of the original ligand 3'-azido-2'-fluoro-dideoxyuridine into the active site. No inhibition by N'-(2,4-dimethoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | Escherichia coli | |
N'-(2,3-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(2,4-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(2,5-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(2-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(2-methoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(3,4-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(3,5-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(3-chlorobenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(3-hydroxy-4-methoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(3-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(4-(dimethylamino)benzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(4-chlorobenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli | |
N'-(4-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0C037 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ppnP | - |
Escherichia coli |
pyrimidine/purine nucleoside phosphorylase | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0011 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(2,4,6-trihydroxybenzylidene)acetohydrazide | |
0.0012 | - |
pH 7.4, 25°C | Escherichia coli | N'-(2,3-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0014 | - |
pH 7.4, 25°C | Escherichia coli | N'-(3,4-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0039 | - |
pH 7.4, 25°C | Escherichia coli | N'-(3,5-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0048 | - |
pH 7.4, 25°C | Escherichia coli | N'-(3-hydroxy-4-methoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0056 | - |
pH 7.4, 25°C | Escherichia coli | N'-(2,4-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0066 | - |
pH 7.4, 25°C | Escherichia coli | N'-(2-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0082 | - |
pH 7.4, 25°C | Escherichia coli | N'-(4-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0092 | - |
pH 7.4, 25°C | Escherichia coli | N'-(2,5-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0116 | - |
pH 7.4, 25°C | Escherichia coli | methyl-4-((2-(2-(2-methyl-1H-indol-3-yl)acetyl)hydrazono)methyl)benzoate | |
0.0132 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(4-nitrobenzylidene)acetohydrazide | |
0.0158 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(2-nitrobenzylidene)acetohydrazide | |
0.0184 | - |
pH 7.4, 25°C | Escherichia coli | N'-(3-chlorobenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0185 | - |
pH 7.4, 25°C | Escherichia coli | N'-(3-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0199 | - |
pH 7.4, 25°C | Escherichia coli | N'-(4-chlorobenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0222 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(2-methylbenzylidene)acetohydrazide | |
0.0222 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(3-nitrobenzylidene)acetohydrazide | |
0.0311 | - |
pH 7.4, 25°C | Escherichia coli | N'-(4-(dimethylamino)benzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0361 | - |
pH 7.4, 25°C | Escherichia coli | N'-(2-methoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide | |
0.0381 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(4-methylbenzylidene)acetohydrazide | |
0.03868 | - |
pH 7.4, 25°C | Escherichia coli | 7-deazaxanthine | |
0.0411 | - |
pH 7.4, 25°C | Escherichia coli | 2-(2-methyl-1H-indol-3-yl)-N'-(3-methylbenzylidene)acetohydrazide |