Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-bromo-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.0244 mM | Escherichia coli | |
5-bromo-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.16 mM | Homo sapiens | |
5-bromo-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.0066 mM | Escherichia coli | |
5-bromo-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.181 mM | Homo sapiens | |
5-chloro-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.0217 mM | Escherichia coli | |
5-chloro-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.115 mM | Homo sapiens | |
5-chloro-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.007 mM | Escherichia coli | |
5-chloro-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.2 mM | Homo sapiens | |
6-[(2'-aminoimidazol-1'-yl)methyl]-5-bromouracil | IC50: 0.0000187 mM | Escherichia coli | |
6-[(2'-aminoimidazol-1'-yl)methyl]-5-bromouracil | IC50: 0.000019 mM | Homo sapiens | |
6-[(2'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | IC50: below 0.0000206 mM | Escherichia coli | |
6-[(2'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | IC50: below 0.000049 mM | Homo sapiens | |
6-[(2'-aminoimidazol-1'-yl)methyl]uracil | IC50: 0.00056 mM | Escherichia coli | |
6-[(2'-aminoimidazol-1'-yl)methyl]uracil | IC50: 0.0001 mM | Homo sapiens | |
6-[(2'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.0024 mM | Escherichia coli | |
6-[(2'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.2577 mM | Homo sapiens | |
6-[(4'-aminoimidazol-1'-yl)methyl]-5-bromouracil | IC50: 0.00065 mM | Escherichia coli | |
6-[(4'-aminoimidazol-1'-yl)methyl]-5-bromouracil | IC50: 0.041 mM | Homo sapiens | |
6-[(4'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | IC50: 0.00073 mM | Escherichia coli | |
6-[(4'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | IC50: 0.026 mM | Homo sapiens | |
6-[(4'-aminoimidazol-1'-yl)methyl]uracil | IC50: 0.1014 mM | Escherichia coli | |
6-[(4'-aminoimidazol-1'-yl)methyl]uracil | IC50: 0.143 mM | Homo sapiens | |
6-[(4'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.0138 mM | Escherichia coli | |
6-[(4'-nitroimidazol-1'-yl)methyl]uracil | IC50: 0.5 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.16 | - |
5-nitro-2'-deoxyuridine | pH 7.4, 25°C | Homo sapiens | |
0.23 | - |
5-nitro-2'-deoxyuridine | pH 7.4, 25°C | Escherichia coli | |
0.24 | - |
thymidine | pH 7.4, 25°C | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | P19971 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-nitro-2'-deoxyuridine + phosphate | - |
Escherichia coli | 5-nitrouracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
5-nitro-2'-deoxyuridine + phosphate | - |
Homo sapiens | 5-nitrouracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.88 | - |
5-nitro-2'-deoxyuridine | pH 7.4, 25°C | Homo sapiens | |
20 | - |
5-nitro-2'-deoxyuridine | pH 7.4, 25°C | Escherichia coli | |
1770 | - |
thymidine | pH 7.4, 25°C | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000187 | - |
IC50: 0.0000187 mM | Escherichia coli | 6-[(2'-aminoimidazol-1'-yl)methyl]-5-bromouracil | |
0.000019 | - |
IC50: 0.000019 mM | Homo sapiens | 6-[(2'-aminoimidazol-1'-yl)methyl]-5-bromouracil | |
0.0000206 | - |
IC50: below 0.0000206 mM | Escherichia coli | 6-[(2'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | |
0.000049 | - |
IC50: below 0.000049 mM | Homo sapiens | 6-[(2'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | |
0.0001 | - |
IC50: 0.0001 mM | Homo sapiens | 6-[(2'-aminoimidazol-1'-yl)methyl]uracil | |
0.00056 | - |
IC50: 0.00056 mM | Escherichia coli | 6-[(2'-aminoimidazol-1'-yl)methyl]uracil | |
0.00065 | - |
IC50: 0.00065 mM | Escherichia coli | 6-[(4'-aminoimidazol-1'-yl)methyl]-5-bromouracil | |
0.00073 | - |
IC50: 0.00073 mM | Escherichia coli | 6-[(4'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | |
0.0024 | - |
IC50: 0.0024 mM | Escherichia coli | 6-[(2'-nitroimidazol-1'-yl)methyl]uracil | |
0.0066 | - |
IC50: 0.0066 mM | Escherichia coli | 5-bromo-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | |
0.007 | - |
IC50: 0.007 mM | Escherichia coli | 5-chloro-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | |
0.0138 | - |
IC50: 0.0138 mM | Escherichia coli | 6-[(4'-nitroimidazol-1'-yl)methyl]uracil | |
0.0217 | - |
IC50: 0.0217 mM | Escherichia coli | 5-chloro-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | |
0.0244 | - |
IC50: 0.0244 mM | Escherichia coli | 5-bromo-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | |
0.026 | - |
IC50: 0.026 mM | Homo sapiens | 6-[(4'-aminoimidazol-1'-yl)methyl]-5-chlorouracil | |
0.041 | - |
IC50: 0.041 mM | Homo sapiens | 6-[(4'-aminoimidazol-1'-yl)methyl]-5-bromouracil | |
0.1014 | - |
IC50: 0.1014 mM | Escherichia coli | 6-[(4'-aminoimidazol-1'-yl)methyl]uracil | |
0.115 | - |
IC50: 0.115 mM | Homo sapiens | 5-chloro-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | |
0.143 | - |
IC50: 0.143 mM | Homo sapiens | 6-[(4'-aminoimidazol-1'-yl)methyl]uracil | |
0.16 | - |
IC50: 0.16 mM | Homo sapiens | 5-bromo-6-[(2'-nitroimidazol-1'-yl)methyl]uracil | |
0.181 | - |
IC50: 0.181 mM | Homo sapiens | 5-bromo-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | |
0.2 | - |
IC50: 0.2 mM | Homo sapiens | 5-chloro-6-[(4'-nitroimidazol-1'-yl)methyl]uracil | |
0.2577 | - |
IC50: 0.2577 mM | Homo sapiens | 6-[(2'-nitroimidazol-1'-yl)methyl]uracil | |
0.5 | - |
IC50: 0.5 mM | Homo sapiens | 6-[(4'-nitroimidazol-1'-yl)methyl]uracil |