Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Clostridium perfringens | Q46220 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no substrates: alpha-skeletal muscle actin, alpha-smooth muscle actin or alpha-cardiac muscle actin. The N-terminal region of actin isoforms define the substrate specificity for ADP-ribosylation by Clostridium botulinum C2 toxin | Clostridium botulinum | ? | - |
? | |
NAD+ + actin | Clostridium botulinum C2 toxin ADP-ribosylates actin isoforms gizzard gamma-smooth muscle actin, spleen beta- and gamma-cytoplasmic actin, and gamma-smooth muscle actin isoforms of aortic smooth muscle actin | Clostridium botulinum | nicotinamide + H+ + (ADP-ribosyl)-actin | - |
? | |
NAD+ + actin | Clostridium perfringens iota toxin ADP-ribosylates all actin isoforms tested, i.e. alpha-skeletal muscle actin, alpha-cardiac muscle actin, gizzard gamma-smooth muscle actin, spleen beta- and gamma-cytoplasmic actin, and aortic smooth muscle actin containing alpha- and gamma-smooth muscle actin isoforms | Clostridium perfringens | nicotinamide + H+ + (ADP-ribosyl)-actin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C2 toxin | - |
Clostridium botulinum |