Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.17 extracted from

  • Dall-Larsen, T.; Kryvi, H.; Klungsoyr, L.
    Dinitrophenol, dicoumarol and pentachlorophenol as inhibitors and parasite substrates in the ATP phosphoribosyltransferase reaction (1976), Eur. J. Biochem., 66, 443-446.
    View publication on PubMed
Search for more literature for 2.4.2.17

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol competitive with respect to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate Escherichia coli
dinitrophenol diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate Escherichia coli
L-histidine feed-back inhibition Escherichia coli
additional information carbonylcyanide m-chlorophenylhydrazone, which is a potent inhibitor of several enzymes with adenine-containing substrates or coenzymes has no effect Escherichia coli
Pentachlorophenol competitive to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Escherichia coli first step in histidine biosynthesis diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Escherichia coli 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis Escherichia coli diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
 ?