Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipid | no absolute requirement for phospholipid, the phospholipid is required for interaction of the enzyme with the long chain polyisoprenol substrate dolichyl phosphate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Amphomycin | 0.03 mg/ml, 50% inhibition | Rattus norvegicus | |
GDP | 0.0013 mM, 50% inhibition | Rattus norvegicus | |
GMP | 0.016 mM, 50% inhibition | Rattus norvegicus | |
GTP | 0.003 mM, 50% inhibition | Rattus norvegicus | |
Nonidet P-40 | 0.01%, 50% inhibition | Rattus norvegicus | |
p-hydroxymercuribenzoate | 0.003 mM, 50% inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
dolichyl phosphate | - |
Rattus norvegicus | |
0.00069 | - |
GDPmannose | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | 5 mM, divalent metal required, 90% of the activation with 5 mM Mn2+ | Rattus norvegicus | |
Mg2+ | 5 mM, divalent metal required, 70% of the activation with 5 mM Mn2+ | Rattus norvegicus | |
Mn2+ | 5 mM, divalent cation required, highest activation with Mn2+ | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDPmannose + dolichyl phosphate | - |
Rattus norvegicus | GDP + dolichyl D-mannosyl phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Rattus norvegicus |