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Literature summary for 2.4.1.47 extracted from
- Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase) (1996), Genomics, 35, 223-226.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CGT gene is cloned, sequenced and characterized, cell-specific and highly time-regulated expression of the gene | Mus musculus |
| cloning and characterization of the CGT gene, chromosomal localization as a single-copy gene to 4q26 | Homo sapiens |
| cloning of the full-length CGT cDNA, open reading frame of 1623 bp encodes a 541 amino acids core protein | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | translation product with N-terminal 20 amino acids signal sequence, C-terminal 23 amino acids transmembrane domain and KKVK endoplasmic reticulum retention signal | Rattus norvegicus | 5783 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | with C-terminal 23 amino acids transmembrane domain | Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
x * 64000 | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | - |
? | - |
? |  |
| additional information | Rattus norvegicus | - |
? | - |
? | |
| additional information | Mus musculus | key enzyme in the biosynthesis of cerebrosides and sulfatides, cell-specific and highly time-regulated expression of the CGT gene is thought to play an important role in oligodendrocyte and Schwann cell differentiation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
| glycoprotein | high mannose glycoprotein | Rattus norvegicus |
| glycoprotein | translation product with 3 putative N-glycosylation sites | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Homo sapiens | ? | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | key enzyme in the biosynthesis of cerebrosides and sulfatides, cell-specific and highly time-regulated expression of the CGT gene is thought to play an important role in oligodendrocyte and Schwann cell differentiation | Mus musculus | ? | - |
? | |
| UDPgalactose + 2-(2-hydroxyacyl)sphingosine | - |
Mus musculus | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | - |
? | |
| UDPgalactose + 2-(2-hydroxyacyl)sphingosine | - |
Homo sapiens | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | - |
? | |
| UDPgalactose + 2-(2-hydroxyacyl)sphingosine | - |
Rattus norvegicus | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 64000 | Rattus norvegicus |
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