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Literature summary for 2.4.1.322 extracted from

  • Nakayama, A.; Okano, A.; Feng, Y.; Collins, J.C.; Collins, K.C.; Walsh, C.T.; Boger, D.L.
    Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate (2014), Org. Lett., 16, 3572-3575.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.322

Application

Application Comment Organism
synthesis in vitro sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and total synthesis of vancomycin and derivatives Amycolatopsis orientalis

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Amycolatopsis orientalis

Organism

Organism UniProt Comment Textmining
Amycolatopsis orientalis Q9AFC7
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Amycolatopsis orientalis ATCC 19795 Q9AFC7
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin
-
 Amycolatopsis orientalis dTDP + vancomycin
-
 ?
dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin
-
 Amycolatopsis orientalis ATCC 19795 dTDP + vancomycin
-
 ?
additional information modification of the C- or N-terminus of the vancomycin aglycon does not inhibit completion of the transfer reaction Amycolatopsis orientalis ?
-
 ?
additional information modification of the C- or N-terminus of the vancomycin aglycon does not inhibit completion of the transfer reaction Amycolatopsis orientalis ATCC 19795 ?
-
 ?
UDP-beta-L-vancosamine + desvancosaminyl-vancomycin
-
 Amycolatopsis orientalis dUDP + vancomycin
-
 ?
UDP-beta-L-vancosamine + desvancosaminyl-vancomycin
-
 Amycolatopsis orientalis ATCC 19795 dUDP + vancomycin
-
 ?