Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis, expression of a truncated form, consisting of the putative catalytic domain, in Spodoptera frugiperda Sf21 insect cells as a soluble FLAG-tagged protein | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + glucuronylgalactosyl glycosides | Homo sapiens | involved in chondroitin initiation and elongation | UDP + N-acetyl-D-galactosaminylglucuronylgalactosyl glycosides | - |
? | |
UDP-N-acetyl-D-galactosamine + glucuronylgalactosyl glycosides | Homo sapiens | involved in the biosynthesis of chodroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core. | UDP + N-acetyl-D-galactosaminylglucuronylgalactosyl glycosides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TDX6 | chondroitin sulfate N-acetylgalactosaminyltransferase | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | low content | Homo sapiens | - |
bone marrow | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
cerebral cortex | - |
Homo sapiens | - |
colon | low content | Homo sapiens | - |
G-361 cell | melanoma cell line | Homo sapiens | - |
kidney | very low content | Homo sapiens | - |
leukocyte | low content | Homo sapiens | - |
liver | very low content | Homo sapiens | - |
lung | low content | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | very high content | Homo sapiens | - |
small intestine | high content | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
SW-1736 cell | thyroid cancer cell line | Homo sapiens | - |
testis | low content | Homo sapiens | - |
thymus | low content | Homo sapiens | - |
thyroid gland | very high content | Homo sapiens | - |
U266 cell | myeloma cell line | Homo sapiens | - |
uterus | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-beta-D-xylose-O-methoxyphenyl | i.e. linkage tetrasaccharide, synthetic substrate | Homo sapiens | UDP + N-acetyl-D-galactosamine-1,4-beta-D-glucuronyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-beta-D-xylose-O-methoxyphenyl | - |
? | |
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-beta-D-xylose-O-methoxyphenyl | best acceptor substrate together with chondroitin polysaccharide | Homo sapiens | UDP + N-acetyl-D-galactosamine-1,4-beta-D-glucuronyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-beta-D-xylose-O-methoxyphenyl | - |
? | |
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-beta-D-xylose-O-methoxyphenyl | transfers GalNAc to GlcA at the non-reducing terminus of the linkage tetrasacharide | Homo sapiens | UDP + N-acetyl-D-galactosamine-1,4-beta-D-glucuronyl-1,3-beta-D-galactosyl-1,3-beta-D-galactosyl-beta-D-xylose-O-methoxyphenyl | - |
? | |
UDP-N-acetyl-D-galactosamine + glucuronylgalactosyl glycosides | - |
Homo sapiens | UDP + N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronylgalactosyl glycosides | - |
? | |
UDP-N-acetyl-D-galactosamine + glucuronylgalactosyl glycosides | involved in chondroitin initiation and elongation | Homo sapiens | UDP + N-acetyl-D-galactosaminylglucuronylgalactosyl glycosides | - |
? | |
UDP-N-acetyl-D-galactosamine + glucuronylgalactosyl glycosides | involved in the biosynthesis of chodroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core. | Homo sapiens | UDP + N-acetyl-D-galactosaminylglucuronylgalactosyl glycosides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme has also N-acetylgalactosaminyltransferase II activity, EC 2.4.1.175, substrates chondroitin oligo- and polysaccharides | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |