Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | Homo sapiens | - |
UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-GlcNAc-(1->4)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09327 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chorionic villus | - |
Homo sapiens | - |
cytotrophoblast | - |
Homo sapiens | - |
decidua | - |
Homo sapiens | - |
HTR-8/SVneo cell | decreased expression of GnT-III in H/R-exposed HTR8/SVneo cells, and the invasive and migratory abilities of HTR8/SVneo cells were attenuated, too | Homo sapiens | - |
additional information | human first trimester villous tissues from normal pregnancies and third trimester placentas from pregnancies with or without preeclampsia (PE) are used for the detection of GnTIII expression | Homo sapiens | - |
placenta | enzyme GnT-III is strongly expressed in cytotrophoblast (CTBs), syncytiotrophoblast (STBs), and the trophoblast columns (TCs) of human placental villi, and decidual cells in maternal decidua. The expression of GnT-III is decreased in preeclampsia placentas compared with the normal control placentas | Homo sapiens | - |
syncytiotrophoblast | - |
Homo sapiens | - |
trophoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | - |
Homo sapiens | UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-GlcNAc-(1->4)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT-III | - |
Homo sapiens |
N-acetylglucosaminyltransferase III | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition. Excessive oxidative stress can decrease GnT-III expression in trophoblast and the decreased expression of GnT-III may be involved in the development of preeclampsia. Clinical characteristics of preeclampsia group comparedwith normal pregnancy group, overview | Homo sapiens |
metabolism | GnT-III is considered to be a key glycosyltransferase in the N-glycan biosynthetic pathway because the introduction of the bisecting GlcNAc residue suppresses further processing and elongation of the N-glycans catalyzed by GnT-V. So, in the tumor context, GnT-III and GnT-V have generally a dual role where GnT-III acts as metastases suppressors whereas GnT-V is associated with increased malignancy and metastasis | Homo sapiens |
physiological function | N-acetylglucosaminyltransferases III (GnT-III) is one of the most important N-glycosyltransferases encoded by the MGAT3 gene. GnT-III catalyzes the addition of GlcNAc via b1-4 linkage to the b-mannose of the mannosyl core of N-glycans. N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. GnT-III is an important regulator at the maternal-fetal interface during early pregnancy | Homo sapiens |