Literature summary for 2.4.1.102 extracted from

Gonzalez-Vallinas, M.; Vargas, T.; Moreno-Rubio, J.; Molina, S.; Herranz, J.; Cejas, P.; Burgos, E.; Aguayo, C.; Custodio, A.; Reglero, G.; Feliu, J.; Ramirez de Molina, A.
Clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer (2015), Eur. J. Cancer, 51, 1-8.

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Application

Application	Comment	Organism
diagnostics	possible role of GCNT3 gene expression as prognostic marker in colon cancer. Low CNT3 expression is a promising prognostic biomarker for colon cancer that could be used to identify early-stage colon cancer patients at high risk of relapse. The enzyme might also constitute a biomarker to monitor tumour response to chemotherapy in cancer patients	Homo sapiens
medicine	clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer, clinicopathological parameters, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene GCNT3, quantitative reverse-transcription PCR enzyme expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95395	gene GCNT3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon cancer cell	differential expression of GCNT3 gene among tumour samples from stage II colon cancer patients by quantitative reverse-transcription PCR, overview	Homo sapiens	-
additional information	the isozyme is distributed in mucin-secreting tissues along the gastrointestinal tract	Homo sapiens	-
pancreatic cancer cell	-	Homo sapiens	-
SW-620 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
c2GnT-M	-	Homo sapiens
gcnt3	-	Homo sapiens
mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the three chemotherapeutic agents, with different mechanism of action, 5-fluorouracil, bortezomib and paclitaxel significantly induce GCNT3 expression in several cancer cells, but not in drug-unreponsive cells	up

General Information

General Information	Comment	Organism
physiological function	the isozyme shows tumour suppressor properties, together with a role of mucin production in chemotherapy sensitivity in pancreatic cancer	Homo sapiens

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Release 2023.1 (January 2023)