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Literature summary for 2.3.3.5 extracted from
- A non-natural protein rescues cells deleted for a key enzyme in central metabolism (2017), ACS Synth. Biol., 6, 694-700 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P31660 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| propanoyl-CoA + H2O + oxaloacetate | - |
Escherichia coli | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PrpC | - |
Escherichia coli |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Escherichia coli | the de novo protein SynGltA stimulates the prp operon. SynGltA allows cells to recover from a defect in central carbon and energy metabolism by altering the regulation of an alternative metabolic pathway. Specifically, SynGltA dramatically enhances the expression of prpC, a gene encoding methylcitrate synthase in the propionate degradation pathway. This endogenous protein has promiscuous catalytic activity, which when overexpressed, compensates for the deletion of citrate synthase | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved in the propionate degradation pathway | Escherichia coli |
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Release 2023.1 (January 2023)
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