Protein Variants | Comment | Organism |
---|---|---|
C2579G | mutation in catalytic cysteine, loss of E3 ligase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
hTERT-RPE1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [adenomatous polyposis coli]-L-lysine | adenomatous polyposis coli protein functions as a negative regulator of the Wnt signaling pathway | Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[adenomatous polyposis coli]-L-lysine | isoform HECTD1 modifies adenomatous polyposis coli with Lys63 polyubiquitin | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform HectD1 promotes the adenomatous polyposis coli-axin interaction to negatively regulate Wnt signaling. Knockdown of HectD1 diminishes adenomatous polyposis coli ubiquitylation, disrupts the adenomatous polyposis coli-axin interaction, and augments Wnt3a-induced beta-catenin stabilization and signaling | Homo sapiens |