Application | Comment | Organism |
---|---|---|
pharmacology | bile extracts from diclofenac-dosed rats at 200 mg/kg, show the presence of the gamma-GT-mediated diclofenac-S-acyl-glutathione degradation product diclofenac-N-acyl-cysteinylglycine, where a total of 8 microg is excreted 6 h postadministration. When diclofenac-S-acyl-glutathione is incubated with gamma-GT, the GSH adduct is degraded in a linear time-dependent fashion | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diclofenac-S-acyl-glutathione | competitive, completely reversible | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diclofenac-S-acyl-glutathione + Gly | - |
Rattus norvegicus | diclofenac-S-acyl-cysteinylglycine + ? | - |
? |