Application | Comment | Organism |
---|---|---|
medicine | SIRT6 as a potential therapeutic target to prevent astrocyte-mediated motor neuron death in amyotrophic lateral sclerosis (ALS) | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene SIRT6, recombinant overexpression in astrocytes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | SIRT6 overexpression abrogates the toxicity of primary astrocytes expressing ALS-linked mutant SOD1 G93A. SIRT6 plays a central role in the protection conferred by enhancing NAD+ availability in hSOD1G93A astrocytes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [protein]-N6-palmitoyl-L-lysine | Homo sapiens | - |
nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Homo sapiens | - |
spinal cord | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [protein]-N6-palmitoyl-L-lysine | - |
Homo sapiens | nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD+-dependent deacylase | - |
Homo sapiens |
SIRT6 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of SIRT6 in astrocytes by itself abrogates the neurotoxic phenotype of amyotrophic lateral sclerosis (ALS) astrocytes. Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex | Homo sapiens |
physiological function | Sirtuins (SIRTs) are NAD+-dependent deacylases that play a key role in transcription, DNA repair, metabolism, and oxidative stress resistance. Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing amyotrophic lateral sclerosis (ALS)-linked mutant SOD1. SIRT6 induces ARE-driven gene expression in astrocytes. And SIRT6 induces HO-1 and SRXN1 expression in astrocytes. Involvement of an additional protective pathway linking NMN treatment and increased SIRT6 activity to Nrf2 activation and upregulation of antioxidant defenses in astrocytes, overview | Homo sapiens |