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Literature summary for 2.3.1.B41 extracted from

  • Hu, S.; Liu, H.; Ha, Y.; Luo, X.; Motamedi, M.; Gupta, M.P.; Ma, J.X.; Tilton, R.G.; Zhang, W.
    Posttranslational modification of Sirt6 activity by peroxynitrite (2015), Free Radic. Biol. Med., 79, 176-185.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y12F the mutant exhibits deacetylase activity similar to that of the wild type enzyme Homo sapiens
Y148F the mutant shows 57% decrease of activity compared to the wild type enzyme Homo sapiens
Y257F the mutant shows 73% decrease of activity compared to the wild type enzyme Homo sapiens
Y5F the mutant exhibits deacetylase activity similar to that of the wild type enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-morpholinosydnonimine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
nitrosylation tyrosine 257 in sirtuin 6 is nitrated after 3-morpholinosydnonimine treatment Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
retinal microvascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT6
-
 Homo sapiens
sirtuin 6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens