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Literature summary for 2.3.1.B41 extracted from

  • Hwang, B.J.; Jin, J.; Gao, Y.; Shi, G.; Madabushi, A.; Yan, A.; Guan, X.; Zalzman, M.; Nakajima, S.; Lan, L.; Lu, A.L.
    SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp (2015), BMC Mol. Biol., 16, 12.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
G60A inactive Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine Mus musculus
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P59941
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin Mus musculus ?
-
 ?
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Mus musculus nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT6
-
 Mus musculus
sirtuin 6
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Mus musculus