Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is unaffected by the activators isonicotinamide and resveratrol | Plasmodium falciparum |
Application | Comment | Organism |
---|---|---|
medicine | PfSir2A inhibitors may have therapeutic value in malaria treatment | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli with a C-terminal His6 tag and an N-terminal T7 tag | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | splitomicin and sirtinol fail to inhibit PfSir2 | Plasmodium falciparum | |
nicotinamide | inhibits the deacetylation of native histones much more effectively than deacetylation of a synthetic substrate | Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
x * 30000, SDS-PAGE | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8IE47 | - |
- |
Plasmodium falciparum isolate 3D7 | Q8IE47 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [histone H3]-N6-acetyl-L-lysine | - |
Plasmodium falciparum | nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + [histone H3]-N6-acetyl-L-lysine | - |
Plasmodium falciparum isolate 3D7 | nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + [histone H4]-N6-acetyl-L-lysine | - |
Plasmodium falciparum | nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + [histone H4]-N6-acetyl-L-lysine | - |
Plasmodium falciparum isolate 3D7 | nicotinamide + [histone H4]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 30000, SDS-PAGE | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
Sir2A | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Plasmodium falciparum |