Protein Variants | Comment | Organism |
---|---|---|
C165A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
E167A | highly reduced ability to confer resistance to kanamycin and amikacin | Klebsiella pneumoniae |
E172A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
G170A | mutant enzyme confers high-level resistance to kanamycin but loses the ability to confer resistance to amikacin | Klebsiella pneumoniae |
G175A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
I163A | the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic | Klebsiella pneumoniae |
K168A | the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic | Klebsiella pneumoniae |
L160A | the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic | Klebsiella pneumoniae |
N159A | mutant enzyme confers high-level resistance to kanamycin but loses the ability to confer resistance to amikacin | Klebsiella pneumoniae |
P155A | the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic | Klebsiella pneumoniae |
P157A | the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic | Klebsiella pneumoniae |
Q174A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
R164A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
R173A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
S156A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
S158A | mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type | Klebsiella pneumoniae |
S158A | the MICs of amikacin and kanamycin are higher than those for the wild-type enzyme | Klebsiella pneumoniae |
Y166A | mutant enzyme confers high-level resistance to kanamycin but loses the ability to confer resistance to amikacin | Klebsiella pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Klebsiella pneumoniae | involved in resistance to antibiotics | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | Q93TA5 | plasmid pJHC-MW1 mutant AAC6'-IbG175A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TA6 | plasmid pJHC-MW1 mutant AAC6'-IbQ174A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TA7 | plasmid pJHC-MW1 mutant AAC6'-IbR173A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TA8 | plasmid pJHC-MW1 mutant AAC6'-IbE172A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TA9 | plasmid pJHC-MW1 mutant AAC6'-IbF171A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB0 | plasmid pJHC-MW1 mutant AAC6'-IbG170A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB1 | plasmid pJHC-MW1 mutant AAC6'-IbK168A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB2 | plasmid pJHC-MW1 mutant AAC6'-IbE167A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB3 | plasmid pJHC-MW1 mutant AAC6'-IbY166A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB4 | plasmid pJHC-MW1 mutant AAC6'-IbC165A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB5 | plasmid pJHC-MW1 mutant AAC6'-IbR164A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB6 | plasmid pJHC-MW1 mutant AAC6'-IbI163A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB7 | plasmid pJHC-MW1 mutant AAC6'-IbR161A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB8 | plasmid C-MW1 mutant AAC6'-IbL160A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TB9 | plasmid C-MW1 mutant AAC6'-IbN159A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TC0 | plasmid pJHC-MW1 mutant AAC6'-IbS158A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TC1 | plasmid pJHC-MW1 mutant AAC6'-IbP157A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TC2 | plasmid pJHC-MW1 mutant AAC6'-IbS156A 6'-N-acetyltransferase gene | - |
Klebsiella pneumoniae | Q93TC3 | plasmid pJHC-MW1 mutant AAC6'-IbP155A 6'-N-acetyltransferase gene | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | acetylation reaction occurs through a direct mechanism rather than a ping-pong mechanism that includes a transient transfer of the acetyl group to a cysteine residue | Klebsiella pneumoniae | ? | - |
? | |
additional information | involved in resistance to antibiotics | Klebsiella pneumoniae | ? | - |
? |