Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-amyloid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | Homo sapiens | - |
CoA + O-acetylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28329 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | - |
Homo sapiens | CoA + O-acetylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ChAT | - |
Homo sapiens |
choline acetyltransferase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme activity is reduced significantly when neurons are exposed to high levels of beta-amyloid aggregates | down |
General Information | Comment | Organism |
---|---|---|
malfunction | the reduction in levels of O-acetylcholine is one of the most significant physiological symptoms of Alzheimer's disease | Homo sapiens |