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Literature summary for 2.3.1.5 extracted from

  • Gao, S.; Tan, H.; Lang, L.; Bai, J.; Ji, Y.
    The effect of alpha-solanine on the activity, gene expression, and kinetics of arylamine N-acetyltransferase in HepG2 cells (2018), Oncol. Rep., 39, 2427-2435 .
    View publication on PubMed
Search for more literature for 2.3.1.5

Inhibitors

Inhibitors Comment Organism Structure
alpha-solanine noncompetitive, alpha-solanine can significantly decrease NAT activity in intact Hep-G2 cells or the cytoplasm. Km does not differ either for intact HepG2 cells or for the cytoplasm, while Vmax is significantly different Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00222
-
 2-Aminofluorene Hep-G2 cells, presence of alpha-solanine, pH 7.5, 37°C Homo sapiens
0.00237
-
 2-Aminofluorene Hep-G2 cells, pH 7.5, 37°C Homo sapiens
0.00895
-
 2-Aminofluorene cytosol preparation, pH 7.5, 37°C Homo sapiens
0.00948
-
 2-Aminofluorene cytosol preparation, presence of alpha-solanine, pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-aminofluorene
-
 Homo sapiens CoA + N-acetyl-2-aminofluorene
-
 ?

Expression

Organism Comment Expression
Homo sapiens alpha-solanine can decrease the expression of both NAT1 mRNA and NAT2 mRNA down