General Stability | Organism |
---|---|
acetyl-CoA stabilizes the enzyme form PCAF | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DNA | acetylation of histone H1by the enzymes PCAF and GNC5 is inhibited in vivo by complexing of H1 with DNA | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | Homo sapiens | histone H1 is not acetylated in vivo | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Homo sapiens GCN5 | histone H1 is not acetylated in vivo | CoA + acetylhistone | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
GCN5 | - |
Homo sapiens | - |
recombinant enzyme hPCAF, i.e. human p300/CBP associated factor | - |
Homo sapiens GCN5 | - |
GCN5 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | histone H1 is not acetylated in vivo | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Homo sapiens GCN5 | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | histone H1 is not acetylated in vivo | Homo sapiens GCN5 | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone H1 | histone H1 poor substrate | Homo sapiens | CoA + acetylhistone H1 | - |
? | |
acetyl-CoA + histone H1 | acetylation of histone H1 only in vitro | Homo sapiens | CoA + acetylhistone H1 | - |
? | |
acetyl-CoA + histone H1 | histone H1 poor substrate | Homo sapiens GCN5 | CoA + acetylhistone H1 | - |
? | |
acetyl-CoA + histone H1 | acetylation of histone H1 only in vitro | Homo sapiens GCN5 | CoA + acetylhistone H1 | - |
? | |
acetyl-CoA + histone H4 | histone H4 is the preferred substrate | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + histone H4 | histone H4 is the preferred substrate | Homo sapiens GCN5 | CoA + acetylhistone H4 | - |
? |